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New Publication
Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain
This study describes a previously unappreciated mechanism of astrocyte-neuron metabolic communication through glycogen breakdown in the spinal cord that fuels spinal neuron hyperexcitability.
New Publication
Cellular and Molecular Mechanisms Underlying Pain Chronicity
Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs. Moreover, conventional therapies are not very effective in reducing pain; in fact, clinicians report only 50 percent pain relief among patients who respond to treatments. Since chronic pain is not a pure prolongation of acute pain, but is based on structural and functional alterations of neural circuity, understanding the molecular mechanisms underlying these alterations is crucial for developing new effective therapies.
