Molecular and transcriptional control of neuronal morphology Mauceri working group
Neuronal cells depend on to their distinctive shape to function. Neuronal performance is affected by morphological alterations, which are associated with many cognitive diseases. Although the mechanisms governing neuronal architecture have become better understood, their translational potential is still unexplored. We investigate the molecular and cellular mechanisms that control neural shape and function. This fundamental aspect of our research is followed by an exploration of the results' translational implications in diseases of the nervous system. As such, structural anomalies may not cause the disease, but preventing or correcting them could be beneficial.
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New Publication
Cellular and Molecular Mechanisms Underlying Pain Chronicity
Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs. Moreover, conventional therapies are not very effective in reducing pain; in fact, clinicians report only 50 percent pain relief among patients who respond to treatments. Since chronic pain is not a pure prolongation of acute pain, but is based on structural and functional alterations of neural circuity, understanding the molecular mechanisms underlying these alterations is crucial for developing new effective therapies.
Publications
- Aksan, Bahar; Mauceri, Daniela: Beyond vessels : unraveling the impact of VEGFs on neuronal functions and structure : review / Bahar Aksan, Daniela Mauceri, 06 March 2025. - 21 S. : Illustrationen
In: Journal of biomedical science, ISSN 1423-0127. 32(2025), 1, Artikel-ID 33, Seite 1-21
DOI: 10.1186/s12929-025-01128-8 - Padovani, Alessandro; Pilotto, Andrea; Pelucchi, Silvia; D’Andrea, Laura; Stringhi, Ramona; Gorla, Federica; Aksan, Bahar; Caratozzolo, Salvatore; Benussi, Alberto; Galli, Alice; Tirloni, Clara; Mauceri, Daniela; Canale, Antonio; Archetti, Silvana; Borroni, Barbara; Di Luca, Monica; Marcello, Elena: Cerebrospinal fluid cyclase-associated protein 2 is increased in Alzheimer’s disease and correlates with tau pathology / Alessandro Padovani, Andrea Pilotto, Silvia Pelucchi, Laura D’Andrea, Ramona Stringhi, Federica Gorl… , 16 January 2025. - 4 S. : Illustrationen
In: Translational neurodegeneration, ISSN 2047-9158. 14(2025), Artikel-ID 1, Seite 1-4
DOI: 10.1186/s40035-024-00462-5 - Aksan, Bahar; Kenkel, Ann-Kristin; Yan, Jing; Sánchez Romero, Javier; Missirlis, Dimitris; Mauceri, Daniela: VEGFD signaling balances stability and activity-dependent structural plasticity of dendrites / Bahar Aksan, Ann-Kristin Kenkel, Jing Yan, Javier Sánchez Romero, Dimitris Missirlis, Daniela Maucer… , 19 August 2024. - 28 S. : Illustrationen
In: Cellular and molecular life sciences, ISSN 1420-9071. 81(2024), Artikel-ID 354, Seite 1-28
DOI: 10.1007/s00018-024-05357-2 - Simonetti, Manuela; Mauceri, Daniela: Cellular and molecular mechanisms underlying pain chronicity / Manuela Simonetti and Daniela Mauceri, 11 April 2023. - 5 S.
In: Cells, ISSN 2073-4409. 12(2023), 8 vom: Apr., Artikel-ID 1126, Seite 1-5
DOI: 10.3390/cells12081126 - Figlia, Gianluca; Müller, Sandra; Hertle, Anna M.; Kleber, Susanne; Roiuk, Mykola; Quast, Jan-Philipp; ten Bosch, Nora; Carvajal Ibáñez, Damián; Mauceri, Daniela; Martín-Villalba, Ana; Teleman, Aurelio A.: Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition / Gianluca Figlia, Sandra Müller, Anna M. Hagenston, Susanne Kleber, Mykola Roiuk, Jan-Philipp Quast, … , 12 September 2022. - 15 S.
In: Nature cell biology, ISSN 1476-4679. 24(2022), 9, Seite 1407-1421
DOI: 10.1038/s41556-022-00977-x - Franchini, Luca; Stanic, Jennifer; Barzasi, Marta; Zianni, Elisa; Mauceri, Daniela; Diluca, Monica; Gardoni, Fabrizio: Rabphilin-3A drives structural modifications of dendritic spines induced by long-term potentiation / Luca Franchini, Jennifer Stanic, Marta Barzasi, Elisa Zianni, Daniela Mauceri, Monica Diluca and Fab… , 11 May 2022. - 16 S.
In: Cells, ISSN 2073-4409. 11(2022), 10, special issue, Artikel-ID 1616, Seite 1-16
DOI: 10.3390/cells11101616 - Litke, Christian; Hertle, Anna M.; Kenkel, Ann-Kristin; Paldy, Eszter; Lu, Jianning; Kuner, Rohini; Mauceri, Daniela: Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice / Christian Litke, Anna M. Hagenston, Ann-Kristin Kenkel, Eszter Paldy, Jianning Lu, Rohini Kuner, Dan… , 15 February 2022. - 11 S.
In: Nature Communications, ISSN 2041-1723. 13(2022), Artikel-ID 875, Seite 1-11
DOI: 10.1038/s41467-022-28357-x - Mauceri, Daniela; Kuner, Rohini: Protecting against summation of pain / Daniela Mauceri and Rohini Kuner, 2022. - 3 S. : Illustrationen
In: Neuron, ISSN 1097-4199. 110(2022), 16, Seite 2513-2515
DOI: 10.1016/j.neuron.2022.07.008 - Mauceri, Daniela: Role of epigenetic mechanisms in chronic pain / Daniela Mauceri, 22 August 2022. - 16 S.
In: Cells, ISSN 2073-4409. 11(2022), 16, Artikel-ID 2613, Seite 1-16
DOI: 10.3390/cells11162613 - Spitzel, Marlene; Wagner, Elise; Breyer, Maximilian; Henniger, Dorothea; Bayin, Mehtap; Hofmann, Lukas; Mauceri, Daniela; Sommer, Claudia; Üçeyler, Nurcan: Dysregulation of immune response mediators and pain-related ion channels is associated with pain-like behavior in the GLA KO mouse model of fabry disease / Marlene Spitzel, Elise Wagner, Maximilian Breyer, Dorothea Henniger, Mehtap Bayin, Lukas Hofmann, Da… , 24 May 2022. - 21 S.
In: Cells, ISSN 2073-4409. 11(2022), 11, Artikel-ID 1730, Seite 1-21
DOI: 10.3390/cells11111730 - Simonetti, Manuela; Paldy, Eszter; Njoo, Christian; Bali, Kiran Kumar; Worzfeld, Thomas; Pitzer, Claudia; Kuner, Thomas; Offermanns, Stefan; Mauceri, Daniela; Kuner, Rohini: The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology / Manuela Simonetti, Eszter Paldy, Christian Njoo, Kiran Kumar Bali, Thomas Worzfeld, Claudia Pitzer, … , 2021. - 23 S.
In: Molecular psychiatry, ISSN 1476-5578. 26(2021), 4, Seite 1376-1398
DOI: 10.1038/s41380-019-0491-4 - Mauceri, Daniela; Buchthal, Bettina; Hemstedt, Thekla Joana; Weiss, Ursula; Klein, Christian D.; Bading, Hilmar: Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage / Daniela Mauceri, Bettina Buchthal, Thekla J. Hemstedt, Ursula Weiss, Christian D. Klein, and Hilmar … , March 30, 2020. - 8 S.
In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 1091-6490. 117(2020), 15, Seite 8616-8623
DOI: 10.1073/pnas.2001563117 - Maurer, Jana; Yáñez, Antonio; Bengtson, C. Peter; Bading, Hilmar; Draguhn, Andreas; Mauceri, Daniela; Both, Martin: VEGF-D downregulation in CA1 pyramidal neurons exerts asymmetric changes of dendritic morphology without correlated electrophysiological alterations / Jana Maurer, Antonio Yanez, C. Peter Bengtson, Hilmar Bading, Andreas Draguhn, Daniela Mauceri, Mart… , 11 September 2020. - 15 S.
In: Neuroscience, ISSN 1873-7544. 448(2020), Seite 28-42
DOI: 10.1016/j.neuroscience.2020.09.012 - Carrano, Nicolò; Samaddar, Tanmoy; Mauceri, Daniela: The synaptonuclear messenger RNF10 acts as an architect of neuronal morphology / Nicolò Carrano, Tanmoy Samaddar, Electra Brunialti, Luca Franchini, Elena Marcello, Paolo Ciana, Dan… , 08 May 2019. - 11 S.
In: Molecular neurobiology, ISSN 1559-1182. 56(2019), 11, Seite 7583-7593
DOI: 10.1007/s12035-019-1631-1 - Oliveira, Ana; Litke, Christian; Paldy, Eszter; Kuner, Rohini; Bading, Hilmar; Mauceri, Daniela: Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2 / Ana M.M. Oliveira, Christian Litke, Eszter Paldy, Anna M. Hagenston, Jianning Lu, Rohini Kuner, Hilm… , January 13, 2019. - 10 S.
In: Molecular pain, ISSN 1744-8069. 15(2019)
DOI: 10.1177/1744806919827469 - Schlüter, Annabelle; Roßberger, Sabrina; Dannehl, Dominik; Janssen, Jan Maximilian; Vorwald, Silke; Hanne, Janina; Schultz, Christian; Mauceri, Daniela; Engelhardt, Maren: Dynamic regulation of synaptopodin and the axon initial segment in retinal ganglion cells during postnatal development / Annabelle Schlüter, Sabrina Rossberger, Dominik Dannehl, Jan Maximilian Janssen, Silke Vorwald, Jani… , 30 July 2019
In: Frontiers in cellular neuroscience, ISSN 1662-5102. 13(2019) Artikel-Nummer 318, 18 Seiten
DOI: 10.3389/fncel.2019.00318 - Schlüter, Annabelle; Aksan, Bahar; Fioravanti, Rossella; Valente, Sergio; Mai, Antonello; Mauceri, Daniela: Histone deacetylases contribute to excitotoxicity-triggered degeneration of retinal ganglion cells in vivo / Annabelle Schlüter, Bahar Aksan, Rossella Fioravanti, Sergio Valente, Antonello Mai, Daniela Mauceri, 3 June 2019. - 17 S.
In: Molecular neurobiology, ISSN 1559-1182. 56(2019), 12, Seite 8018-8034
DOI: 10.1007/s12035-019-01658-x - Schlüter, Annabelle; Aksan, Bahar; Diem, Ricarda; Fairless, Richard; Mauceri, Daniela: VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury / Annabelle Schlüter, Bahar Aksan, Ricarda Diem, Richard Fairless, and Daniela Mauceri, 2020. - 19 S.
In: Molecular therapy, ISSN 2329-0501. 17(2020), Seite 281-299
DOI: 10.1016/j.omtm.2019.12.009 - Chandrasekar, Akila; Aksan, Bahar; Mauceri, Daniela: Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses / Akila Chandrasekar, Bahar Aksan, Florian olde Heuvel, Philip Förstner, Daniela Sinske, Rida Rehman, … , [April 2018]. - 12 S.
In: Experimental neurology, ISSN 1090-2430. 302(2018), Seite 34-45
DOI: 10.1016/j.expneurol.2017.12.017 - Litke, Christian; Bading, Hilmar; Mauceri, Daniela: Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of vascular endothelial growth factor D / Christian Litke, Hilmar Bading, and Daniela Mauceri, April 9, 2018. - 13 S.
In: The journal of biological chemistry, ISSN 1083-351X. 293(2018), 21, Seite 8196-8207
DOI: 10.1074/jbc.RA117.001613 - Mauceri, Daniela; Hertle, Anna M.; Schramm, Kathrin; Weiss, Ursula; Bading, Hilmar: Nuclear calcium buffering capacity shapes neuronal architecture / Daniela Mauceri, Anna M. Hagenston, Kathrin Schramm, Ursula Weiss, and Hilmar Bading, July 31, 2015. - 11 S.
In: JBC papers in press, ISSN 1083-351X. 290(2015), 38, Seite 23039-23049
DOI: 10.1074/jbc.M115.654962 - Mauceri, Daniela: Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation / Dr. Daniela Mauceri, 2014. - 2 S. : Illustrationen
In: Jahrbuch der Heidelberger Akademie der Wissenschaften für ..., ISSN 0341-2865. (2013), Seite 284-285
DOI: 10.11588/diglit.55655.96 - Oliveira, Ana; Bading, Hilmar; Mauceri, Daniela: Dysfunction of neuronal calcium signaling in aging and disease / Ana M.M. Oliveira · Hilmar Bading · Daniela Mauceri, 13 July 2014. - 3 S.
In: Cell & tissue research, ISSN 1432-0878. 357(2014), 2, Seite 381-383
DOI: 10.1007/s00441-014-1954-1 - Schlumm, Friederike; Mauceri, Daniela; Freitag, H. Eckehard; Bading, Hilmar: Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity / Friederike Schlumm, Daniela Mauceri, H. Eckehard Freitag, and Hilmar Bading, 2013. - 11 S.
In: The journal of biological chemistry, ISSN 1083-351X. 288(2013), 12, Seite 8074-8084
DOI: 10.1074/jbc.M112.432773 - Simonetti, Manuela; Hertle, Anna M.; Vardeh, Daniel; Freitag, H. Eckehard; Mauceri, Daniela; Lu, Jianning; Bading, Hilmar; Kuner, Rohini: Nuclear calcium signaling in spinal Neurons drives a genomic program required for persistent inflammatory pain / Manuela Simonetti, Anna M. Hagenston, Daniel Vardeh, H. Eckehard Freitag, Daniela Mauceri, Jianning … , 2013. - 15 S.
In: Neuron, ISSN 1097-4199. 77(2013), 1, Seite 43-57
DOI: 10.1016/j.neuron.2012.10.037 - Mauceri, Daniela; Freitag, H. Eckehard; Oliveira, Ana; Bengtson, C. Peter; Bading, Hilmar: Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation / Daniela Mauceri, H. Eckehard Freitag, Ana M.M. Oliveira, C. Peter Bengtson, and Hilmar Bading, 13 July 2011. - 14 S.
In: Neuron, ISSN 1097-4199. 71(2011), 1, Seite 117-130
DOI: 10.1016/j.neuron.2011.04.022