NMDA receptor signaling in health and disease: novel neuroprotective treatment strategies Bading working group
We are interested in neuronal calcium signaling in synapse-to-nucleus communication and in how neuronal activity-regulated gene expression leads to neuroprotection and other adaptive responses in the brain including memory formation. Based on studies of toxic extrasynaptic NMDA receptor signaling, we are developing broad-spectrum neuroprotectants.
Links
New Publication
Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain
This study describes a previously unappreciated mechanism of astrocyte-neuron metabolic communication through glycogen breakdown in the spinal cord that fuels spinal neuron hyperexcitability.
Publications
- Gleitze, Silvia; Ramirez, Omar; Vega-Vásquez, Ignacio; Stefan, Emely; Bengtson, C. Peter; Paula-Lima, Andrea; Bading, Hilmar; Hidalgo, Cecilia: Calcium release via IP3R/RyR channels contributes to the nuclear and mitochondrial Ca2+ signals elicited by neuronal stimulation / Silvia Gleitze, Omar A. Ramírez, Ignacio Vega-Vásquez, Emely Stefan, C. Peter Bengtson, Andrea Paula… , 25 March 2025. - 9 S. : Illustrationen
In: Biochemical and biophysical research communications, ISSN 1090-2104. 754(2025) vom: März, Artikel-ID 151445, Seite 1-9
DOI: 10.1016/j.bbrc.2025.151445 - Ramirez, Omar; Hellwig, Andrea; Zhang, Zihong; Bading, Hilmar: Pharmacological targeting of the NMDAR/TRPM4 death signaling complex with a TwinF interface inhibitor prevents excitotoxicity-associated dendritic blebbing and organelle damage / Omar A. Ramírez, Andrea Hellwig, Zihong Zhang and Hilmar Bading, 28 January 2025. - 15 S. : Illustrationen
In: Cells, ISSN 2073-4409. 14(2025), 3, Artikel-ID 195, Seite 1-15
DOI: 10.3390/cells14030195 - Marty-Lombardi, Sebastián; Lu, Shiying; Ambroziak, Wojciech; Schrenk-Siemens, Katrin; Wang, Jialin; DePaoli-Roach, Anna A.; Hertle, Anna M.; Wende, Hagen; Tappe-Theodor, Anke; Simonetti, Manuela; Bading, Hilmar; Okun, Jürgen G.; Kuner, Rohini; Fleming, Thomas; Siemens, Jan: Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain / Sebastián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Katrin Schrenk-Siemens, Jialin Wang, Anna … , 05 March 2024. - 20 S.
In: Nature metabolism, ISSN 2522-5812. (2024), Seite 1-20
DOI: 10.1038/s42255-024-01001-2 - Marty-Lombardi, Sebastián; Lu, Shiying; Ambroziak, Wojciech; Schrenk-Siemens, Katrin; Wang, Jialin; DePaoli-Roach, Anna A.; Hertle, Anna M.; Wende, Hagen; Tappe-Theodor, Anke; Simonetti, Manuela; Bading, Hilmar; Okun, Jürgen G.; Kuner, Rohini; Fleming, Thomas; Siemens, Jan: Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain [data] / Sebstián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Katrin Schrenk-Siemens, Jialin Wang, Anna A… . -
Heidelberg: Universität, 2024-01-26. - 1 Online-Ressource (2 Files)
DOI: 10.11588/data/AMDH7G - Wang, Yumeng; Yan, Jing; Williams-Fairless, Sarah K.; Fairless, Richard; Bading, Hilmar: TwinF interface inhibitor FP802 prevents retinal ganglion cell loss in a mouse model of amyotrophic lateral sclerosis / Yu Meng Wang, Jing Yan, Sarah K. Williams, Richard Fairless and Hilmar Bading, 12 September 2024. - 9 S. : Illustrationen
In: Acta Neuropathologica Communications, ISSN 2051-5960. 12(2024), 1, Artikel-ID 149, Seite 1-9
DOI: 10.1186/s40478-024-01858-0 - Yan, Jing; Wang, Yumeng; Hellwig, Andrea; Bading, Hilmar: TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS / Jing Yan, Yu Meng Wang, Andrea Hellwig, Hilmar Bading, February 20, 2024. - 9 S.
In: Cell reports, ISSN 2666-3791. 5(2024), 2, Artikel-ID 101413, Seite 1-9
DOI: 10.1016/j.xcrm.2024.101413 - Gleitze, Silvia; Ramirez, Omar; Vega-Vásquez, Ignacio; Yan, Jing; Lobos, Pedro; Bading, Hilmar; Núñez, Marco T.; Paula-Lima, Andrea; Hidalgo, Cecilia: Ryanodine receptor mediated calcium release contributes to ferroptosis induced in primary hippocampal neurons by GPX4 inhibition / Silvia Gleitze, Omar A. Ramírez, Ignacio Vega-Vásquez, Jing Yan, Pedro Lobos, Hilmar Bading, Marco T… , 13 March 2023. - 18 S.
In: Antioxidants, ISSN 2076-3921. 12(2023), 3, Artikel-ID 705, Seite 1-18
DOI: 10.3390/antiox12030705 - Nassrallah, Wissam B.; Ramandi, Daniel; Cheng, Judy; Oh, Jean; Mackay, James; Sepers, Marja D.; Lau, David; Bading, Hilmar; Raymond, Lynn A.: Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease / Wissam B. Nassrallah, Daniel Ramandi, Judy Cheng, Jean Oh, James Mackay, Marja D. Sepers, David Lau,… , 20 November 2023. - 10 S.
In: Neurobiology of disease, ISSN 1095-953X. 189(2023), Artikel-ID 106360, Seite 1-10
DOI: 10.1016/j.nbd.2023.106360 - Pruunsild, Priit; Bengtson, C. Peter; Loss, Isabel; Lohrer, Benjamin; Bading, Hilmar: Expression of the primate-specific LINC00473 RNA in mouse neurons promotes excitability and CREB-regulated transcription / Priit Pruunsild, C. Peter Bengtson, Isabel Loss, Benjamin Lohrer, and Hilmar Bading, May 2023. - 17 S. : Illustrationen
In: The journal of biological chemistry, ISSN 1083-351X. 299(2023), 5 vom: Mai, Artikel-ID 104671, Seite 1-17
DOI: 10.1016/j.jbc.2023.104671 - Yan, Jing; Bading, Hilmar: The disruption of NMDAR/TRPM4 death signaling with TwinF interface inhibitors : a new pharmacological principle for neuroprotection / Jing Yan and Hilmar Bading, 31 July 2023. - 15 S. : Illustrationen
In: Pharmaceuticals, ISSN 1424-8247. 16(2023), 8, Artikel-ID 1085, Seite 1-15
DOI: 10.3390/ph16081085 - Bauersachs, Hanke; Bengtson, C. Peter; Weiss, Ursula; Hellwig, Andrea; García-Vilela, Celia; Zaremba, Bastienne; Kaessmann, Henrik; Pruunsild, Priit; Bading, Hilmar: N-methyl-d-aspartate receptor-mediated preconditioning mitigates excitotoxicity in human induced pluripotent stem cell-derived brain organoids / Hanke Gwendolyn Bauersachs, C. Peter Bengtson, Ursula Weiss, Andrea Hellwig, Celia García-Vilela, Ba… , 21 February 2022. - 15 S.
In: Neuroscience, ISSN 1873-7544. 484(2022), Seite 83-97
DOI: 10.1016/j.neuroscience.2021.12.026 - Fröhlich, Albrecht; Olde Heuvel, Florian; Rehman, Rida; Krishnamurthy, Sruthi Sankari; Li, Shun; Li, Zhenghui; Bayer, David; Conquest, Alison; Hertle, Anna M.; Ludolph, Albert; Huber-Lang, Markus; Boeckers, Tobias; Knöll, Bernd; Morganti-Kossmann, Maria Cristina; Bading, Hilmar; Roselli, Francesco: Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury / Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui… , 19 November 2022. - 25 S.
In: Journal of neuroinflammation, ISSN 1742-2094. 19(2022), Artikel-ID 279, Seite 1-25
DOI: 10.1186/s12974-022-02634-4 - Hertle, Anna M.; Yan, Jing; Bas Orth, Carlos; Tan, Yan-Wei; Sekler, Israel; Bading, Hilmar: Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic / Anna M. Hagenston, Jing Yan, Carlos Bas-Orth, Yanwei Tan, Israel Sekler, and Hilmar Bading, 2022. - 24 S.
In: The journal of biological chemistry, ISSN 1083-351X. 298(2022), 2, Artikel-ID 101508, Seite 1-24
DOI: 10.1016/j.jbc.2021.101508 - Oberländer, Kristin; Witte, Victoria; Mallien, Anne Stephanie; Bengtson, C. Peter; Bading, Hilmar: Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice / Kristin Oberländer, Victoria Witte, Anne Stephanie Mallien, Peter Gass, C. Peter Bengtson and Hilmar… , 2022. - 16 S.
In: Learning & memory, ISSN 1549-5485. 29(2022), 2, Seite 55-70
DOI: 10.1101/lm.053527.121 - Bading, Hilmar: Eine unheilvolle Verbindung : Hoffnung auf Trennung / Hilmar Bading, 2021-07-16. - 8 S.
In: Ruperto Carola, ISSN 0035-998X. 18(2021), Seite 16-23
DOI: 10.17885/heiup.ruca.2021.18.24359 - Fairless, Richard; Bading, Hilmar; Diem, Ricarda: Pathophysiological ionotropic glutamate signalling in neuroinflammatory disease as a therapeutic target / Richard Fairless, Hilmar Bading and Ricarda Diem, 21 October 2021. - 16 S.
In: Frontiers in neuroscience, ISSN 1662-453X. 15(2021), Artikel-ID 1408, Seite 1-16
DOI: 10.3389/fnins.2021.741280 - Lissek, Thomas; Andrianarivelo, Andry; Saint-Jour, Estefani; Allichon, Marie-Charlotte; Bauersachs, Hanke; Nassar, Merie; Piette, Charlotte; Pruunsild, Priit; Tan, Yan-Wei; Forget, Benoit; Heck, Nicolas; Caboche, Jocelyne; Venance, Laurent; Vanhoutte, Peter; Bading, Hilmar: Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion / Thomas Lissek, Andry Andrianarivelo, Estefani Saint-Jour, Marie-Charlotte Allichon, Hanke Gwendolyn … , 18 October 2021. - 16 S.
In: EMBO reports, ISSN 1469-3178. 22(2021), 12 vom: Dez., Artikel-ID e51882, Seite 1-16
DOI: 10.15252/embr.202051882 - Mozolewski, Pawel; Jeziorek, Maciej; Schuster, Christoph M.; Bading, Hilmar; Frost, Bess; Dobrowolski, Radek: The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health / Pawel Mozolewski, Maciej Jeziorek, Christoph M. Schuster, Hilmar Bading, Bess Frost, Radek Dobrowols… , 22 April 2021
In: Journal of cell science, ISSN 1477-9137. 134(2021), 8 vom: Apr., Artikel-ID jcs254904
DOI: 10.1242/jcs.254904 - Bas Orth, Carlos; Koch, Mirja; Lau, David; Buchthal, Bettina; Bading, Hilmar: A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling / Carlos Bas-Orth, Mirja Koch, David Lau, Bettina Buchthal and Hilmar Bading, 10 January 2020. - 10 S.
In: Molecular brain, ISSN 1756-6606. 13(2020,1) Artikel-Nummer 3, 10 Seiten
DOI: 10.1186/s13041-020-0546-0 - Hertle, Anna M.; Bading, Hilmar; Bas Orth, Carlos: Functional consequences of calcium-dependent synapse-to-nucleus communication : focus on transcription-dependent metabolic plasticity / Anna M. Hagenston, Hilmar Bading and Carlos Bas-Orth, [April 2020]. - ? S.
In: Cold Spring Harbor perspectives in biology, ISSN 1943-0264. 12(2020,4) Artikel-Nummer a035287
DOI: 10.1101/cshperspect.a035287 - Mauceri, Daniela; Buchthal, Bettina; Hemstedt, Thekla Joana; Weiss, Ursula; Klein, Christian D.; Bading, Hilmar: Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage / Daniela Mauceri, Bettina Buchthal, Thekla J. Hemstedt, Ursula Weiss, Christian D. Klein, and Hilmar … , March 30, 2020. - 8 S.
In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 1091-6490. 117(2020), 15, Seite 8616-8623
DOI: 10.1073/pnas.2001563117 - Maurer, Jana; Yáñez, Antonio; Bengtson, C. Peter; Bading, Hilmar; Draguhn, Andreas; Mauceri, Daniela; Both, Martin: VEGF-D downregulation in CA1 pyramidal neurons exerts asymmetric changes of dendritic morphology without correlated electrophysiological alterations / Jana Maurer, Antonio Yanez, C. Peter Bengtson, Hilmar Bading, Andreas Draguhn, Daniela Mauceri, Mart… , 11 September 2020. - 15 S.
In: Neuroscience, ISSN 1873-7544. 448(2020), Seite 28-42
DOI: 10.1016/j.neuroscience.2020.09.012 - Merz, Simon; Bengtson, C. Peter; Tepohl, Clara; Hertle, Anna M.; Bading, Hilmar; Bas Orth, Carlos: A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir / Simon F. Merz, C. Peter Bengtson, Clara Tepohl, Anna M. Hagenston, Hilmar Bading, and Carlos Bas-Ort… , 14 September 2020. - 14 S.
In: Molecular brain, ISSN 1756-6606. 13(2020) Artikel-Nummer 124, 14 Seiten
DOI: 10.1186/s13041-020-00641-1 - Yan, Jing; Bengtson, C. Peter; Buchthal, Bettina; Hertle, Anna M.; Bading, Hilmar: Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants / Jing Yan, C. Peter Bengtson, Bettina Buchthal, Anna M. Hagenston, Hilmar Bading, 09 Oct 2020. - 8 S.
In: Science, ISSN 1095-9203. 370(2020,6513) Artikel-Nummer eaay3302, 8 Seiten
DOI: 10.1126/science.aay3302 - Yan, Jing; Bengtson, C. Peter; Buchthal, Bettina; Hertle, Anna M.; Bading, Hilmar: Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants / Jing Yan, C. Peter Bengtson, Bettina Buchthal, Anna M. Hagenston, Hilmar Bading, 09 Oct 2020. - 9 S.
In: Science. 370(2020), Artikel-ID 6513, Seite 1-9
DOI: 10.1126/science.aay3302 - Ernst, Anne-Sophie; Böhler, Laura-Inés; Hertle, Anna M.; Hoffmann, Angelika; Heiland, Sabine; Sticht, Carsten; Bendszus, Martin; Hecker, Markus; Bading, Hilmar; Marti, Hugo; Korff, Thomas; Kunze, Reiner: EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke / Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten … . -
London: BioMed Central, 2019. - 1 Online-Ressource
DOI: 10.1186/s40478-019-0669-7 - Ernst, Anne-Sophie; Böhler, Laura-Inés; Hertle, Anna M.; Hoffmann, Angelika; Heiland, Sabine; Sticht, Carsten; Bendszus, Martin; Hecker, Markus; Bading, Hilmar; Marti, Hugo; Korff, Thomas; Kunze, Reiner: EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke / Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten … , 5 February 2019. - 23 S.
In: Acta Neuropathologica Communications, ISSN 2051-5960. 7(2019), Artikel-ID 15, Seite 1-23
DOI: 10.1186/s40478-019-0669-7 - Hasan, Mazahir; Althammer, Ferdinand; Silva da Gouveia, Miriam; Goyon, Stephanie; Eliava, Marina; Lefevre, Arthur; Kerspern, Damien; Schimmer, Jonas; Raftogianni, Androniki; Wahis, Jerome; Knobloch-Bollmann, Hanna Sophie; Tang, Yan; Liu, Xinying; Jain, Apar; Chavant, Virginie; Goumon, Yannick; Weislogel, Jan-Marek; Hurlemann, René; Herpertz, Sabine; Pitzer, Claudia; Darbon, Pascal; Dogbevia, Godwin K.; Bertocchi, Ilaria; Larkum, Matthew E.; Sprengel, Rolf; Bading, Hilmar; Charlet, Alexandre; Grinevich, Valéry: A fear memory engram and its plasticity in the hypothalamic oxytocin system / Mazahir T. Hasan, Ferdinand Althammer, Miriam Silva da Gouveia, Stephanie Goyon, Marina Eliava, Arth… , 16 May 2019. - 26 S.
In: Neuron, ISSN 1097-4199. 103(2019), 1, Seite 133-146
DOI: 10.1016/j.neuron.2019.04.029 - Moldavski, Alexander; Behr, Joachim; Bading, Hilmar; Bengtson, C. Peter: A novel method using ambient glutamate for the electrophysiological quantification of extrasynaptic NMDA receptor function in acute brain slices / Alexander Moldavski, Joachim Behr, Hilmar Bading and C. Peter Bengtson, 2020. - 18 S.
In: The journal of physiology, ISSN 1469-7793. 598(2020), 4, Seite 633-650
DOI: 10.1113/JP278362 - Monaco, Sara; Jahraus, Beate; Samstag, Yvonne; Bading, Hilmar: Conditions of limited calcium influx (CLCI) inhibits IL2 induction and favors expression of anergy-related genes in TCR/CD3 and CD28 costimulated primary human T cells / Sara Monaco, Beate Jahraus, Yvonne Samstag, Hilmar Bading, [October 2019]. - 7 S. : Illustrationen
In: Molecular immunology, ISSN 1872-9142. 114(2019), Seite 81-87
DOI: 10.1016/j.molimm.2019.07.006 - Oliveira, Ana; Litke, Christian; Paldy, Eszter; Kuner, Rohini; Bading, Hilmar; Mauceri, Daniela: Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2 / Ana M.M. Oliveira, Christian Litke, Eszter Paldy, Anna M. Hagenston, Jianning Lu, Rohini Kuner, Hilm… , January 13, 2019. - 10 S.
In: Molecular pain, ISSN 1744-8069. 15(2019)
DOI: 10.1177/1744806919827469 - Pruunsild, Priit; Bading, Hilmar: Shaping the human brain : evolutionary cis-regulatory plasticity drives changes in synaptic activity-controlled adaptive gene expression / Priit Pruunsild, Hilmar Bading, 16 May 2019. - 7 S.
In: Current opinion in neurobiology, ISSN 1873-6882. 59(2019), Seite 34-40
DOI: 10.1016/j.conb.2019.04.003 - Staufer, Oskar; Weber, Sebastian; Bengtson, C. Peter; Bading, Hilmar; Rustom, Amin; Spatz, Joachim P.: Adhesion stabilized en masse intracellular electrical recordings from multicellular assemblies / Oskar Staufer, Sebastian Weber, C. Peter Bengtson, Hilmar Bading, Amin Rustom, and Joachim P. Spatz, 5 April 2019. - 12 S.
In: Nano letters, ISSN 1530-6992. 19(2019), 5, Seite 3244-3255
DOI: 10.1021/acs.nanolett.9b00784 - Baur, Katja; Spanagel, Rainer; Bading, Hilmar; Bengtson, C. Peter: c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo / Katja Baur, Arian Hach, Rick E. Bernardi, Rainer Spanagel, Hilmar Bading, C. Peter Bengtson, 11 June 2018. - 13 S.
In: The journal of comparative neurology, ISSN 1096-9861. 526(2018), 13, Seite 2019-2031
DOI: 10.1002/cne.24471 - Buchthal, Bettina; Weiss, Ursula; Bading, Hilmar: Post-injury nose-to-brain delivery of Activin A and SerpinB2 reduces brain damage in a mouse stroke model / Bettina Buchthal, Ursula Weiss and Hilmar Bading, 23 July 2018. - 9 S.
In: Molecular therapy, ISSN 1525-0024. 26(2018), 10, Seite 2357-2365
DOI: 10.1016/j.ymthe.2018.07.018 - Cannella, Nazzareno; Oliveira, Ana; Hemstedt, Thekla Joana; Lissek, Thomas; Büchler, Elena; Bading, Hilmar; Spanagel, Rainer: Dnmt3a2 in the nucleus accumbens shell is required for reinstatement of cocaine seeking / Nazzareno Cannella, Ana M.M. Oliveira, Thekla Hemstedt, Thomas Lissek, Elena Buechler, Hilmar Bading… , [August 22, 2018]. - 13 S.
In: The journal of neuroscience, ISSN 1529-2401. 38(2018), 34, Seite 7516-7528
DOI: 10.1523/JNEUROSCI.0600-18.2018 - Chandrasekar, Akila; Heuvel, Florian olde; Tar, Lilla; Hertle, Anna M.; Palmer, Annette; Linkus, Birgit; Ludolph, Albert C.; Huber-Lang, Markus; Boeckers, Tobias; Bading, Hilmar; Roselli, Francesco: Parvalbumin interneurons shape neuronal vulnerability in blunt TBI / Akila Chandrasekar, Florian olde Heuvel, Lilla Tar, Anna M. Hagenston, Annette Palmer, Birgit Linkus… , 2019. - 15 S.
In: Cerebral cortex, ISSN 1460-2199. 29(2019), 6, Seite 2701-2715
DOI: 10.1093/cercor/bhy139 - Chandrasekar, Akila; Hertle, Anna M.; Bading, Hilmar: Parvalbumin interneurons shape neuronal vulnerability in blunt TBI / Akila Chandrasekar, Florian olde Heuvel, Lilla Tar, Anna M. Hagenston, Annette Palmer, Birgit Linkus… , 30 June 2018 : Illustrationen
In: Cerebral cortex, ISSN 1460-2199. 29(2019), 6, Seite 2701-2715
DOI: 10.1093/cercor/bhy139 - Litke, Christian; Bading, Hilmar; Mauceri, Daniela: Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of vascular endothelial growth factor D / Christian Litke, Hilmar Bading, and Daniela Mauceri, April 9, 2018. - 13 S.
In: The journal of biological chemistry, ISSN 1083-351X. 293(2018), 21, Seite 8196-8207
DOI: 10.1074/jbc.RA117.001613 - Bading, Hilmar: Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations / Hilmar Bading. - 10 S.
In: Journal of experimental medicine, ISSN 1540-9538. 214(2017), 3, S. 569-578
DOI: 10.1084/jem.20161673 - Bas Orth, Carlos; Tan, Yan-Wei; Lau, David; Bading, Hilmar: Synaptic activity drives a genomic program that promotes a neuronal Warburg effect / Carlos Bas-Orth, Yan-Wei Tan, David Lau, and Hilmar Bading. - 12 S.
In: The journal of biological chemistry, ISSN 1083-351X. 292(2017), 13, S. 5183-5194
DOI: 10.1074/jbc.M116.761106 - Depp, Constanze; Bas Orth, Carlos; Hellwig, Andrea; Bading, Hilmar: Synaptic activity protects neurons against calcium-mediated oxidation and contraction of mitochondria during excitotoxicity / Constanze Depp, Carlos Bas-Orth, Lisa Schroeder, Andrea Hellwig, and Hilmar Bading, 2018. - 32 S.
In: Antioxidants & redox signaling, ISSN 1557-7716. 29(2018), 12, Seite 1130-1161
DOI: 10.1089/ars.2017.7092 - Hardingham, Giles E.; Pruunsild, Priit; Bading, Hilmar: Lineage divergence of activity-driven transcription and evolution of cognitive ability / Giles E. Hardingham, Priit Pruunsild, Michael E. Greenberg and Hilmar Bading, 2018. - 7 S.
In: Nature reviews, ISSN 1471-0048. 19(2018), 1, Seite 9-15
DOI: 10.1038/nrn.2017.138 - Hemstedt, Thekla Joana; Bengtson, C. Peter; Oliveira, Ana; Bading, Hilmar: Reciprocal interaction of dendrite geometry and nuclear calcium-VEGFD signaling gates memory consolidation and extinction / Thekla J. Hemstedt, C. Peter Bengtson, Omar Ramírez, Ana M.M. Oliveira, and Hilmar Bading, May 9, 2017. - 10 S.
In: The journal of neuroscience, ISSN 1529-2401. 37(2017), 29, Seite 6946-6955
DOI: 10.1523/JNEUROSCI.2345-16.2017 - Lissek, Thomas; Bading, Hilmar; Draguhn, Andreas; Grinevich, Valéry; Koehr, Georg; Spanagel, Rainer: Building bridges through science / Thomas Lissek, Michelle Adams, John Adelman, Ehud Ahissar, Mohammed Akaaboune, Huda Akil, Mustafa al… , 2017. - 6 S.
In: Neuron, ISSN 1097-4199. 96(2017), 4, Seite 730-735
DOI: 10.1016/j.neuron.2017.09.028 - Pruunsild, Priit; Bengtson, C. Peter; Bading, Hilmar: Networks of cultured iPSC-derived neurons reveal the human synaptic activity-regulated adaptive gene program / Priit Pruunsild, C. Peter Bengtson, Hilmar Bading, January 3, 2017. - 5 S.
In: Cell reports, ISSN 2211-1247. 18(2017), 1, Seite 122-135
DOI: 10.1016/j.celrep.2016.12.018 - Yu, Yan; Oberländer, Kristin; Bengtson, C. Peter; Bading, Hilmar: One nuclear calcium transient induced by a single burst of action potentials represents the minimum signal strength in activity-dependent transcription in hippocampal neurons / Yan Yu, Kristin Oberlaender, C. Peter Bengtson, Hilmar Bading, 6 March 2017. - 8 S.
In: Cell calcium, ISSN 1532-1991. 65(2017), Seite 14-21
DOI: 10.1016/j.ceca.2017.03.003 - Bas Orth, Carlos; Tan, Yan-Wei; Oliveira, Ana; Bengtson, C. Peter; Bading, Hilmar: The calmodulin-binding transcription activator CAMTA1 is required for long-term memory formation in mice / Carlos Bas-Orth, Yan-Wei Tan, Ana M. M. Oliveira, C. Peter Bengtson, and Hilmar Bading, 2016. - 9 S.
In: Learning & memory, ISSN 1549-5485. 23(2016), 6, Seite 313-321
DOI: 10.1101/lm.041111.115 - Monaco, Sara; Jahraus, Beate; Samstag, Yvonne; Bading, Hilmar: Nuclear calcium is required for human T cell activation / Sara Monaco, Beate Jahraus, Yvonne Samstag, and Hilmar Bading. - 13 S.
In: The journal of cell biology, ISSN 1540-8140. 215(2016), 2, S. 231-243
DOI: 10.1083/jcb.201602001 - Staufer, Oskar; Weber, Sebastian; Bengtson, C. Peter; Bading, Hilmar; Spatz, Joachim P.; Rustom, Amin: Functional fusion of living systems with synthetic electrode interfaces / Oskar Staufer, Sebastian Weber, C. Peter Bengtson, Hilmar Bading, Joachim P. Spatz and Amin Rustom, 26 February 2016. - 6 S.
In: Beilstein journal of nanotechnology, ISSN 2190-4286. 7(2016), Seite 296-301
DOI: 10.3762/bjnano.7.27 - Kostic, Marko; Ludtmann, Marthe H. R.; Bading, Hilmar; Hershfinkel, Michal; Steer, Erin; Chu, Charleen T.; Abramov, Andrey Y.; Sekler, Israel: PKA phosphorylation of NCLX reverses mitochondrial calcium overload and depolarization, promoting survival of PINK1-deficient dopaminergic neurons / Marko Kostic, Marthe H.R. Ludtmann, Hilmar Bading, Michal Hershfinkel, Erin Steer, Charleen T. Chu, … , October 1, 2015. - 11 S.
In: Cell reports, ISSN 2211-1247. 13(2015), 2, Seite 376-386
DOI: 10.1016/j.celrep.2015.08.079 - Lau, David; Bengtson, C. Peter; Buchthal, Bettina; Bading, Hilmar: BDNF reduces toxic extrasynaptic NMDA receptor signaling via synaptic NMDA receptors and nuclear-calcium-induced transcription of inhba/Activin A / authors: David Lau ; C. Peter Bengtson ; Bettina Buchthal ; Hilmar Bading. - 14 S.
In: Cell reports, ISSN 2211-1247. 12(2015), 8, S. 1353-1366
DOI: 10.1016/j.celrep.2015.07.038 - Mauceri, Daniela; Hertle, Anna M.; Schramm, Kathrin; Weiss, Ursula; Bading, Hilmar: Nuclear calcium buffering capacity shapes neuronal architecture / Daniela Mauceri, Anna M. Hagenston, Kathrin Schramm, Ursula Weiss, and Hilmar Bading, July 31, 2015. - 11 S.
In: JBC papers in press, ISSN 1083-351X. 290(2015), 38, Seite 23039-23049
DOI: 10.1074/jbc.M115.654962 - Oliveira, Ana; Hemstedt, Thekla Joana; Freitag, H. Eckehard; Bading, Hilmar: Dnmt3a2 - a hub for enhancing cognitive functions / A. M. M. Oliveira, T. J. Hemstedt, H. E. Freitag and H. Bading. - Advance online publ., 2015
In: Molecular psychiatry, ISSN 1476-5578. 21(2016), Seite 1130-1136
DOI: 10.1038/mp.2015.175 - Živković, Aleksandar; Sedlaczek, Oliver; Haken, Rebecca von; Schmidt, Karsten; Brenner, Thorsten; Weigand, Markus A.; Bading, Hilmar; Bengtson, C. Peter; Hofer, Stefan: Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity / Aleksandar R. Zivkovic, Oliver Sedlaczek, Rebecca von Haken, Karsten Schmidt, Thorsten Brenner, Mark… , 04 November 2015. - 12 S.
In: Acta Neuropathologica Communications, ISSN 2051-5960. 3(2015), Artikel-ID 67, Seite 1-12
DOI: 10.1186/s40478-015-0245-8 - Živković, Aleksandar; Sedlaczek, Oliver; Haken, Rebecca von; Schmidt, Karsten; Brenner, Thorsten; Weigand, Markus A.; Bading, Hilmar; Bengtson, C. Peter; Hofer, Stefan: Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity / Aleksandar R. Zivkovic, Oliver Sedlaczek, Rebecca von Haken, Karsten Schmidt, Thorsten Brenner, Mark… . -
London: BioMed Central, 2015. - 1 Online-Ressource (12 Seiten) - Ahlgren, Hanna Henrika; Bas Orth, Carlos; Freitag, H. Eckehard; Hellwig, Andrea; Ottersen, Ole Petter; Bading, Hilmar: The nuclear calcium signaling target, activating transcription factor 3 (ATF3), protects against dendrotoxicity and facilitates the recovery of synaptic transmission after an excitotoxic insult / Hanna Ahlgren, Carlos Bas-Orth, H. Eckehard Freitag, Andrea Hellwig, Ole Petter Ottersen, and Hilmar… , February 10, 2014. - 13 S.
In: The journal of biological chemistry, ISSN 1083-351X. 289(2014), 14, Seite 9970-9982
DOI: 10.1074/jbc.M113.502914 - Bading, Hilmar: Hirnjogging / Hilmar Bading. -
Heidelberg: Universitätsbibliothek Heidelberg, 2014. - Online-Ressource (00:02:01 Std.) - Hayer, Stefanie Nicole; Bading, Hilmar: Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2 / Stefanie N. Hayer, Hilmar Bading, 2015. - 10 S.
In: The journal of biological chemistry, ISSN 1083-351X. 290(2015), 9, Seite 5523-5532
DOI: 10.1074/jbc.M113.532010 - Oliveira, Ana; Bading, Hilmar; Mauceri, Daniela: Dysfunction of neuronal calcium signaling in aging and disease / Ana M.M. Oliveira · Hilmar Bading · Daniela Mauceri, 13 July 2014. - 3 S.
In: Cell & tissue research, ISSN 1432-0878. 357(2014), 2, Seite 381-383
DOI: 10.1007/s00441-014-1954-1 - Bading, Hilmar; Schuster, Christoph M.: Dem Langzeitgedächtnis auf der Spur / Hilmar Bading ; Christoph Schuster. -
Heidelberg: Universitätsbibliothek Heidelberg, 2013. - Online-Ressource - Bading, Hilmar: Nuclear calcium signalling in the regulation of brain function / Hilmar Bading, 14 August 2013. - 16 S.
In: Nature reviews, ISSN 1471-0048. 14(2013), 9, Seite 593-608
DOI: 10.1038/nrn3531 - Bengtson, C. Peter; Kaiser, Martin Erich; Obermayer, Joshua; Bading, Hilmar: Calcium responses to synaptically activated bursts of action potentials and their synapse-independent replay in cultured networks of hippocampal neurons / C. Peter Bengtson, Martin Kaiser, Joshua Obermayer, Hilmar Bading, 26 January 2013. - 8 S.
In: Biochimica et biophysica acta, ISSN 1879-2596. 1833(2013), 7, Seite 1672-1679
DOI: 10.1016/j.bbamcr.2013.01.022 - Qiu, Jing; Tan, Yan-Wei; Hertle, Anna M.; Martel, Marc-Andre; Kneisel, Niclas; Skehel, Paul A.; Wyllie, David J. A.; Bading, Hilmar; Hardingham, Giles E.: Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals / Jing Qiu, Yan-Wei Tan, Anna M. Hagenston, Marc-Andre Martel, Niclas Kneisel, Paul A. Skehel, David J… , 18 Jun 2013. - 12 S.
In: Nature Communications, ISSN 2041-1723. 4(2013), Artikel-ID 2034, Seite 1-12
DOI: 10.1038/ncomms3034 - Schlumm, Friederike; Mauceri, Daniela; Freitag, H. Eckehard; Bading, Hilmar: Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity / Friederike Schlumm, Daniela Mauceri, H. Eckehard Freitag, and Hilmar Bading, 2013. - 11 S.
In: The journal of biological chemistry, ISSN 1083-351X. 288(2013), 12, Seite 8074-8084
DOI: 10.1074/jbc.M112.432773 - Simonetti, Manuela; Hertle, Anna M.; Vardeh, Daniel; Freitag, H. Eckehard; Mauceri, Daniela; Lu, Jianning; Bading, Hilmar; Kuner, Rohini: Nuclear calcium signaling in spinal Neurons drives a genomic program required for persistent inflammatory pain / Manuela Simonetti, Anna M. Hagenston, Daniel Vardeh, H. Eckehard Freitag, Daniela Mauceri, Jianning … , 2013. - 15 S.
In: Neuron, ISSN 1097-4199. 77(2013), 1, Seite 43-57
DOI: 10.1016/j.neuron.2012.10.037 - Weislogel, Jan-Marek; Bengtson, C. Peter; Schuster, Christoph M.; Bading, Hilmar: Requirement for nuclear valcium signaling in drosophila long-term memory / J. M. Weislogel ; C. P. Bengtson ... C. M. Schuster ; H. Bading. - ? S.
In: Science signaling, ISSN 1937-9145. 6(2013), 274, S. ra33
DOI: 10.1126/scisignal.2003598 - Bas Orth, Carlos; Bading, Hilmar: The divergence-convergence model of acquired neuroprotection / Carlos Bas-Orth, Hilmar Bading, 2013. - 6 S.
In: Mechanisms of development, ISSN 1872-6356. 130(2013), 6, Seite 396-401
DOI: 10.1016/j.mod.2012.09.008 - Bengtson, C. Peter; Bading, Hilmar: Nuclear Calcium signaling / C. Peter Bengtson, Hilmar Bading. - 29 S.
In: Synaptic Plasticity. (2012), S. 377-405
DOI: 10.1007/978-3-7091-0932-8_17 - Buchthal, Bettina; Lau, David; Weiss, Ursula; Weislogel, Jan-Marek; Bading, Hilmar: Nuclear calcium signaling controls nethyl-CpG-binding protein 2 (MeCP2) phosphorylation on serine 421 following synaptic activity / Bettina Buchthal, David Lau, Ursula Weiss, Jan-Marek Weislogel, and Hilmar Bading. - 8 S.
In: The journal of biological chemistry, ISSN 1083-351X. 287(2012), 37, S. 30967-30974
DOI: 10.1074/jbc.M112.382507 - Oliveira, Ana; Hemstedt, Thekla Joana; Bading, Hilmar: Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities / Ana M.M. Oliveira, Thekla J. Hemstedt & Hilmar Bading, 1 July 2012. - 3 S.
In: Nature neuroscience, ISSN 1546-1726. 15(2012), 8, Seite 1111-1113
DOI: 10.1038/nn.3151 - Reichinnek, Susanne; Hertle, Anna M.; Freitag, H. Eckehard; Roth, Fabian C.; Bading, Hilmar; Draguhn, Andreas; Both, Martin: Reliable optical detection of coherent neuronal activity in fast oscillating networks in vitro / Susanne Reichinnek ... Anna M. Hagenston, Eckehard Freitag, Fabian C. Roth, Hilmar Bading ... Andrea… , 2012. - 14 S.
In: NeuroImage, ISSN 1095-9572. 60(2012), Seite 139-152
DOI: 10.1016/j.neuroimage.2011.12.018 - Tan, Yan-Wei; Hoffmann, Tina; Bading, Hilmar: Increasing levels of wild-type CREB up-regulates several activity-regulated inhibitor of death (AID) genes and promotes neuronal survival / Yan-Wei Tan, Sheng-Jia Zhang, Tina Hoffmann, and Hilmar Bading, 18 May 2012. - 9 S.
In: BMC neuroscience, ISSN 1471-2202. 13(2012) Artikel-Nummer 48, 9 Seiten
DOI: 10.1186/1471-2202-13-48 - Bading, Hilmar: Schlaganfall : ein Gen, das vor den Folgen eines Schlaganfalles schützt, haben Wissenschaftler der Universität Heidelberg entdeckt / Hilmar Bading. -
Heidelberg: Universitätsbibliothek der Universität Heidelberg, 2011. - Online-Ressource
(Campus-Report bei Uni-Radio Baden ; 18. Mai 2011) - Hertle, Anna M.; Bading, Hilmar: Calcium signaling in synapse-to-nucleus communication / Anna M. Hagenston and Hilmar Bading, 2011. - 33 S.
In: Cold Spring Harbor perspectives in biology, ISSN 1943-0264. 3(2011), 11, Artikel-ID a004564, Seite 1-33-
DOI: 10.1101/cshperspect.a004564 - Mauceri, Daniela; Freitag, H. Eckehard; Oliveira, Ana; Bengtson, C. Peter; Bading, Hilmar: Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation / Daniela Mauceri, H. Eckehard Freitag, Ana M.M. Oliveira, C. Peter Bengtson, and Hilmar Bading, 13 July 2011. - 14 S.
In: Neuron, ISSN 1097-4199. 71(2011), 1, Seite 117-130
DOI: 10.1016/j.neuron.2011.04.022 - Oliveira, Ana; Bading, Hilmar: Calcium signaling in cognition and aging-dependent cognitive decline / Ana MM Oliveira and Hilmar Bading, 22 June 2011. - 6 S.
In: Biofactors, ISSN 1872-8081. 37(2011), 3 vom: Mai/Juni, Seite 168-174
DOI: 10.1002/biof.148 - Queisser, Sean Gillian; Wiegert, Simon; Bading, Hilmar: Structural dynamics of the cell nucleus / Gillian Queisser, Simon Wiegert and Hilmar Bading, 01 March 2011. - 7 S.
In: Nucleus, ISSN 1949-1042. 2(2011), 2, Seite 98-104
DOI: 10.4161/nucl.2.2.15116 - Wiegert, Simon; Bading, Hilmar: Activity-dependent calcium signaling and ERK-MAP kinases in neurons : a link to structural plasticity of the nucleus and gene transcription regulation / J. Simon Wiegert, Hilmar Bading, 2011. - 10 S.
In: Cell calcium, ISSN 1532-1991. 49(2011), 5 vom: Mai, Seite 296-305
DOI: 10.1016/j.ceca.2010.11.009 - Zhang, Sheng-Jia; Buchthal, Bettina; Lau, David; Hayer, Stefanie Nicole; Dick, Oliver; Schwaninger, Markus; Veltkamp, Roland; Zou, Ming; Weiss, Ursula; Bading, Hilmar: A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage / Sheng-Jia Zhang, Bettina Buchthal, David Lau, Stefanie Hayer, Oliver Dick, Markus Schwaninger, Rolan… , March 30, 2011. - 13 S.
In: The journal of neuroscience, ISSN 1529-2401. 31(2011), 13, Seite 4978-4990
DOI: 10.1523/JNEUROSCI.2672-10.2011 - Bengtson, C. Peter; Freitag, H. Eckehard; Weislogel, Jan-Marek; Bading, Hilmar: Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons / C. Peter Bengtson, H. Eckehard Freitag, Jan-Marek Weislogel, and Hilmar Bading, 14 December 2010. - 12 S.
In: Biophysical journal, ISSN 1542-0086. 99(2010), 12, Seite 4066-4077
DOI: 10.1016/j.bpj.2010.10.044 - Dick, Oliver; Bading, Hilmar: Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors / Oliver Dick and Hilmar Bading, 19 April 2010. - 8 S. : Illustrationen
In: The journal of biological chemistry, ISSN 1083-351X. 285(2010), 25 vom: Juni, Seite 19354-19361
DOI: 10.1074/jbc.M110.127654 - Maus, Lisa; Dick, Oliver; Bading, Hilmar; Spatz, Joachim P.; Fiammengo, Roberto: Conjugation of peptides to the passivation shell of gold nanoparticles for targeting of cell-surface receptors / Lisa Maus, Oliver Dick, Hilmar Bading, Joachim P. Spatz, and Roberto Fiammengo, October 12, 2010. - 12 S.
In: ACS nano, ISSN 1936-086X. 4(2010), 11, Seite 6617-6628
DOI: 10.1021/nn101867w - Bading, Hilmar: Geistige Aktivität schützt das Gehirn : der Heidelberger Neurowissenschaftler Hilmar Bading hat herausgefunden, warum das so ist / Hilmar Bading. -
Heidelberg: Universitätsbibliothek der Universität Heidelberg, 2009. - Online-Ressource
(Campus-Report bei Uni-Radio Baden ; 14. Okt. 2009) - Hofmann, F.; Bading, Hilmar: Long-term recordings with microelectrode arrays : studies of transcription-dependent neuronal plasticity and axonal regeneration / Hofmann, F. and Bading, H., 2006. - 8 S.
In: Journal of physiology Paris, ISSN 0928-4257. 99(2006), Seite 125-132 - Wittmann, Malte; Bengtson, C. Peter; Bading, Hilmar: Extrasynaptic NMDA receptors : Mediators of excitotoxic cell death / Malte Wittmann; C. Peter Bengtson; Hilmar Bading. -
Heidelberg: Universitätsbibliothek der Universität Heidelberg, 2005. - Online-Ressource - Bading, Hilmar: Quercetinhemmechanismus der Calciumtransport-ATPase des sarkoplasmatischen Retikulums : Isolierung d. 55000-Fragments d. trypt. verdauten Calciumtransport-ATPase d. sarkoplasmat. Retikulums ohne denaturierendes Detergenz / vorgelegt von Hilmar Bading, 1984. - II, 58 Bl. : graph. Darst.