Mechanisms of experience-dependent synaptic plasticity, learning & memory and memory extinction Schuster working group
The physiological, cellular and molecular characterization of synaptic plasticity and higher brain functions such as learning & memory is often hindered by the high complexity of mammalian brains. We therefore apply powerful genetic, physiological and behavioral tools established in the fruit fly Drosophila melanogaster to study experience-dependent synaptic potentiation of larval glutamatergic synapses with high resolution as well as long-term memory (LTM) formation and LTM-extinction using an olfactory conditioning paradigm in adult flies. Our research aims at facilitating the identification of the principal mechanisms underlying higher brain functions.
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Neuroscience Major
Those with a desire to make it in neuroscience need a broad spectrum of skills and knowledge encompassing multiple disciplines and techniques, as well as social skills, networking, and an eagerness to learn new things even outside of your original discipline. The Heidelberg Neuroscience Major provides all of this to highly motivated and independently thinking students.
Publications
- Mozolewski, Pawel; Jeziorek, Maciej; Schuster, Christoph M.; Bading, Hilmar; Frost, Bess; Dobrowolski, Radek: The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health / Pawel Mozolewski, Maciej Jeziorek, Christoph M. Schuster, Hilmar Bading, Bess Frost, Radek Dobrowols… , 22 April 2021
In: Journal of cell science, ISSN 1477-9137. 134(2021), 8 vom: Apr., Artikel-ID jcs254904
DOI: 10.1242/jcs.254904 - Schuster, Christoph M.: Von Fliegen und Menschen : Lernen und Vergessen / Christoph Schuster. - 8 S.
In: Ruperto Carola. 9(2016), S. 86-93
DOI: 10.17885/heiup.ruca.2016.9.23615 - Knodel, Markus M.; Geiger, Romina; Ge, Lihao; Bucher, Daniel; Grillo, Alfio; Wittum, Gabriel; Schuster, Christoph M.; Queisser, Sean Gillian: Synaptic bouton properties are tuned to best fit the prevailing firing pattern / Markus M. Knodel, Romina Geiger, Lihao Ge, Daniel Bucher, Alfio Grillo, Gabriel Wittum, Christoph M.… , 09 September 2014 : Illustrationen
In: Frontiers in computational neuroscience, ISSN 1662-5188. 8(2014) Artikel-Nummer 101, 16 Seiten
DOI: 10.3389/fncom.2014.00101 - Bading, Hilmar; Schuster, Christoph M.: Dem Langzeitgedächtnis auf der Spur / Hilmar Bading ; Christoph Schuster. -
Heidelberg: Universitätsbibliothek Heidelberg, 2013. - Online-Ressource - Berger, Angelika; Hoelbl-Kovacic, A.; Bourgeais, J.; Hoefling, L.; Warsch, W.; Grundschober, E.; Uras, I. Z.; Menzl, I.; Putz, E. M.; Hoermann, G.; Schuster, Christoph M.; Fajmann, S.; Leitner, E.; Kubicek, S.; Moriggl, R.; Gouilleux, F.; Sexl, V.: PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis / A. Berger, A. Hoelbl-Kovacic, J. Bourgeais, L. Hoefling, W. Warsch, E. Grundschober, I.Z. Uras, I. M… , 2014. - 13 S.
In: Leukemia, ISSN 1476-5551. 28(2014), 3, Seite 629-641
DOI: 10.1038/leu.2013.351 - Weislogel, Jan-Marek; Bengtson, C. Peter; Schuster, Christoph M.; Bading, Hilmar: Requirement for nuclear valcium signaling in drosophila long-term memory / J. M. Weislogel ; C. P. Bengtson ... C. M. Schuster ; H. Bading. - ? S.
In: Science signaling, ISSN 1937-9145. 6(2013), 274, S. ra33
DOI: 10.1126/scisignal.2003598 - Jochum, Tobias; Schuster, Christoph M.: Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures / Tobias Jochum, Manuela E. Ritz, Christoph Schuster, Sarah F. Funderburk, Katja Jehle, Katja Schmitz,… . - 9 S.
In: Biochimica et biophysica acta, ISSN 1879-260X. 1822(2012), 6, S. 1070-1078
DOI: 10.1016/j.bbadis.2012.02.006 - Schuster, Christoph M.: Molekulare Untersuchung der glutamatergen Signalübertragung von Drosophila melanogaster : Klonierung und Charakterisierung einer muskulären Glutamatrezeptor-Untereinheit / vorgelegt von Christoph Maria Schuster, 1992. - 79 S. : Ill., graph. Darst.